

Actor portrayal
Actor portrayal
PH1, PH2, and PH3, the 3 known primary hyperoxaluria (PH) subtypes, are caused by missing or malfunctioning enzymes
Each of the 3 known PH subtypes is caused by a genetic mutation that keeps the liver from making a specific enzyme.
PH1
Caused by genetic mutation resulting in missing or malfunctioning
PH2
Caused by genetic mutation resulting in missing or malfunctioning
PH3
Caused by genetic mutation resulting in missing or malfunctioning
Why are these missing enzymes a problem?
When one of these enzymes is missing or malfunctioning, it causes glyoxylate to build up in the liver.
Another liver enzyme called lactate dehydrogenase (LDH) converts this glyoxylate into excessive levels of oxalate.
PH subtypes, symptom onset, and disease progression
- PH1
- PH2
- PH3
Living with your subtype
Here's what current management options look like for PH.